Can Exipure Activate BAT (Brown Adipose Tissue) & Burn Fat?

Updated 3/25/22. Exipure is a popular slimming supplement designed to tackle the real root cause of belly fat -not enough brown adipose fat. Taking this radical approach to weight loss is making it the talk of the internet. While it's a popular appetite suppressant for those trying to get into better shape and maintain their weight, in this honest Exipure review, you'll discover revealing information -worts and all – to know about before you make a purchase. You'll also learn about the Exipure guarantee, pros and cons, research and proof, and how to get your money returned to you if it's not working for you. Affiliate Disclosure: This site contains affiliate links which means if you decide to make a purchase after clicking a link this site will make a small commission. The company pays this not you. See the affiliate disclosure page for more information.

How Does Exipure Truly Work?

According to the company, Exipure increases your production of brown adipose tissue (BAT), also known as brown fat. Brown fat, first discovered in the year 1551 plays a role in non-shivering thermogenesis and has a higher metabolic rate than the more common, white adipose fat, due to its higher concentration of mitochondria. These extra mitochondria produce a greater amount of heat from increased calorie burning. In a fetus, researchers suggest brown fat burns about 300 times more calories than white fat.

If that holds true for adults, in theory, this means if you had more brown adipose fat on your body, your metabolism would be higher and you'd burn more calories. Higher metabolic rates and calorie burning might lead to body weight reduction.  Keep in mind though, that the fat browning effect of Exipure appears to lack human clinical proof.

Exipure Supplement Facts

Those wondering what Exipure is made of should know that each capsule contains these nutrition ingredients and dosages:

Ingredient	Amount	Percent Daily Value
Exipure Formula Blend	300	N/A
Oleuropein Blend composed of:
Olive Leaf and Leaf Extract
Holy Basil
Concentrated Bee Propolis
Berberine
Kudzu Root Extract
Quercetin
White Korean Ginseng (Panax ginseng)
Luteolin

What Does All This Mean?

The supplement facts label may be a bit confusing to some so here is a quick breakdown of what it  means:

1. Each capsule contains 300 mg of a proprietary blend of 9 ingredients
2. Ingredients towards the top make up most of the blend. Those listed at the bottom make up smaller amounts
3. Within the proprietary blend is the Oleuropein Blend which contains olive leaf and olive leaf extract

Exipure Summary of Key Ingredients

What Is The Oleuropein Blend?

Oleuropein is a substance found in olive skin. So both olives and olive oil contain this plant nutrient. The Oleuropein blend is a proprietary blend that is composed of:

1. Olive Leaf (olea europaea)
2. Olive Leaf Extract, standardized to 20% Oleuropein

Olives and their oil are well known for their heart health and blood vessel benefits as part of the Mederterian diet. Beyond that, researchers also find Oleuropein may improve fatty liver disease and reduce belly fat. Still, other research reveals oleuropein may increase the production of brown fat, the more metabolically active form, which may help people shed excess weight. The downside of the proof though is that it is mostly involving animals and needs to be confirmed in people.

On the plus side, olive leaf extract possesses anti-inflammatory, anti-viral benefits and is an antioxidant. Olive leaf extract may also benefit people with type II diabetes, prediabetes and insulin resistance. In one study, olive leaf extract polyphenols improved the function of cells in the pancreas (called Beta cells) that make insulin. This would reduce fasting blood sugar levels.

Olive Leaf Extract: Does OLE Burn Fat?

To discover if olive leaf extract helps people lose weight, researchers recruited 70 overweight women and put them all on a diet. Everyone ate 500 fewer calories a day for 8 weeks. Half of the women combined the diet with 125 mg of olive leaf extract, which contained 50 mg of the bioactive substance called oleuropein. Compared to women who only dieted, the woman who used olive leaf extract had significantly:

• lower body weight (about 9 pounds less)
• less body fat (about 6 pounds less)
• reduced waste circumference ( about 2 inches less)
• reduced body mass index (BMI)

Animal studies have also suggested olive leaf extract promotes weight loss.

In addition to weight loss, women taking olive leaf extract also experienced additional benefits:

1. reduced fasting blood sugar
2. lower total cholesterol and bad LDL cholesterol
3. reduced leptin levels
4. higher adiponectin levels

Holy Basil: Booster of Brown Fat & Brain Power?

Ocimum sanctum, also known as Ocimum tenuiflorum and better known as Holy Basil, has been a popular Ayurvedic herb for thousands of years. One well-studied compound in this herb is called ursolic acid. In one interesting clinical trial, researchers demonstrated that ursolic acid boosted brown fat production and improved the growth of muscles.

One downside however is that these effects need to be conducted in humans. If they are, ursolic acid could be a game-changer in the battle against aging, atrophy and sarcopenia, and weight gain that occurs as we get older.

Researchers have also found holy basil appears to reduce blood sugar in people with type II diabetes. In one clinical trial, holy basil reduced blood sugar by 17.6% compared to those taking a placebo. Other researchers found holy basil toothpaste improved tooth decay.

In theory, holy basil may reduce stress-induced binge eating in light of preliminary research finding this herb can reduce stress-induced changes in corticosterone and acetylcholine levels. Human proof needs to validate these findings.

Bee Propolis: BAT, Artery Health & Supporter of Blood Sugar?

Propolis is the substance from which bees construct their beehives. It is sometimes called “bee glue.” due to its sticky consistency. It's composed of wax, essential oils, pollen, resin and essential oils. Propolis is not the same thing as royal jelly, which is what the queen bee eats and is linked to their longer lifespans.

Propolis is a rich source of terpenes and flavonoids and other substances such as kaempferide, a polyphenol substance that is may have anto-tumor and anti-cancer properties, and apigenin, considered by some to have anti-inflammatory and antifungal effects. Some research finds propolis can reduce the liver enzyme Aspartate Aminotransferase (AST), although it may not reduce alanine aminotransferase  (ALT).

Propolis also contains water-soluble B vitamins as well as vitamin E and magnesium and other minerals. Some research suggests bee propolis may have antibacterial effects, specifically to H. pylori, the GI bacteria linked to stomach ulcers.

Another benefit may be for helping with type II diabetes. In a review of this substance, it was noted propolis lowered fasting blood sugar and hemoglobin A1c levels. While this is encouraging, studies incorporate dosages that may exceed that which is found in Expiure.  Preliminary research suggests bee propolis may have a fat browning effect by promoting brown adipose formation but this needs to be confirmed in humans.

Berberine: Natural Diabetes Support Supplement?

Various studies have revealed that berberine can reduce blood sugar and hemoglobin A1c levels, making it an attractive option for those with type II diabetes and insulin resistance who are looking for natural alternatives. While blood sugar changes may be observed rather quickly, it will take at least 4-5 months to see meaningful declines in A1c levels. Research has also shown health benefits for women who deal with polycystic ovary syndrome (PCOS). Research also suggests berberine (1500 mg/day) boosts brown adipose tissue production as well as helps overweight people drop excess pounds too.  This effect was seen after just 30 days of daily use.

Berberine is well regarded as a heart health supplement given its ability to reduce total cholesterol and bad, LDL cholesterol. It might also raise good HDL cholesterol too.

How Effective is Berberine For Lowering Cholesterol Levels

Watch on my Youtube channel if you prefer

While berberine has its share of true believers, it's not known if Expire contains enough to make a significant dent in blood sugar or cholesterol levels.

Kudzu Root Extract: Reliever of Aches & Pains?

Also called Japanese Arrowroot, Fen Ke, and Vidarikand, Kudzu has been used for thousands of years in Ayurvedic and traditional Chinese medicine. Some researchers have reported kudzu reduces cravings for alcohol, although more research is needed.  Preliminary evidence suggests a crude extract of kudzu flowers may support weight loss and increase brown fat production. This can't be said with certainty about kudzu root extract, which is found in Exipure. It would depend on whether the flower and root extract were the same. It's unknown if kudzu root extract boosts brown fat genesis in people.

Some research finds kudzu may help people shed belly fat. While encouraging a few more studies need to confirm this finding. The supplement company also states kudzu root extract helps reduce body aches and pains. Some proof suggests an isoflavone extract of kudzu called Puerarin relieves low pack pain when injected. We can't yet say that kudzu supplements ease lumbar pain.

Quercetin: Does It Rejuvenate Aging Cells?

Quercetin is an antioxidant phytonutrient found in many foods, such as blueberries, apples, grapes, red wine, and green tea. Some feel quercetin is an anti-aging molecule, although most of its proof stems from giving it to animals.

Men may use quercetin to self-treat problems of enlarged prostate glands. Some researchers have reported positive results with benign prostate hyperplasia (BPH) when quercetin is taken with other ingredients.  While that may be good news for men, it's not known if quercetin by itself, helps prostate problems or how it compares to other herbs.

At least one study reports the combination of quercetin and resveratrol enhances brown adipose tissue production. While this might motivate some people to give Exipure a try, the supplement does not contain significant amounts of resveratrol. On the plus side, some proof exists for quercetin lowering blood pressure.

White Korean Ginseng (Panax ginseng): Healthy Immunity and BAT Activator?

White ginseng is rare as it has been aging for at least four years. Like all plants, ginseng contains thousands of biologically active substances that researchers are still studying. Diverse investigations have noted ginseng may help improve symptoms of libido and erectile dysfunction. Ginseng contains compounds called ginsenosides that are thought to contribute to its health effects. Two specific ginsenosides – called RB2 and RG3 – have some proof that they may boost brown adipose fat production. The research is intriguing, but researchers need to give RB2 and RG3 to people to see if it works in humans.

Amur Cork Bark (Phellodendron): Healthy Heart & Liver Support?

Amur cork bark (Phellodendron amurense) is the bark of the Phellodendron plant, which has been used for centuries to help conditions linked to excess inflammation, such as pain and acne and to ease stress.  Amur cork bark is not specifically listed on the Exipure Nutrition Supplement Facts label, but it is mentioned on the official company website where it is said to:

• boost BAT adipose production (brown fat)
• ease digestion and bloating
• support the heart and liver

Researchers think amur cork bark might protect against the breakdown of joint cartilage, making it possibly effective for osteoarthritis (degenerative joint disorder). Amur cork bark is also a source of berberine, which can reduce both blood cholesterol and blood sugar levels.  Amur cork bark is also found in some weight loss supplements such as Relora.

Luteolin: Nature's Sun Protection Factor?

Luteolin is a flavonoid plant nutrient found in vegetables like celery, broccoli, opinions, and carrots as well as in parsley and apple skins. One of its functions in plants is to protect them from the damaging effects of UVA and UVB radiation. Because of this, luteolin is being investigated to see if it helps reduce inflammation and sun-induced skin aging and wrinkles. Animal research suggests it might do this.

Animal studies also hint that luteolin may help with weight loss and insulin resistance, one of the most devastating signs of type II diabetes. Also intriguing is some researchers are speculating that one of the ways luteolin is beneficial is by its ability to improve gut health.

How Much Does The Exipure Formula Cost: Discounts, Best Deals

Surveying prices online, the cost may vary from as little as about $15 to above $60 a bottle, depending on where you purchase it from. Of course, do your homework and compare supplement facts labels. Getting it at the best price may not guarantee the ingredients are the same as what the company sells it for. Current prices listed on the official company website are:

• 1 bottle (30-day supply): $59
• 3 bottles (90-day supply):$147 ($49 per bottle)
• 6 bottles (6-month supply): $234 ($39 per bottle)

These prices may be different when you see this so double-check the official website for updates, coupons, and discounts.

Exipure Formula Clinical Proof

The official company website lists 14 scientific references to support the benefits of Exipiure. Most of these citations deal with the ingredients in Exipure. Here is a summary of the cited research.

Clinical Study 1

Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High-fat Diet.  This is a mouse study.

Clinical Study 2

Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism. This is a mouse study.

Clinical Study 3

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. This is a review article.

Clinical Study 4

Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota. This is a mouse study.

Clinical Study 5

Ginsenoside Rb1 promotes browning through the regulation of PPARγ in 3T3-L1 adipocytes. This is an animal study.

Clinical Study 6

The Isoflavone-Rich Fraction of the Crude Extract of the Puerariae Flower Increases Oxygen Consumption and BAT UCP1 Expression in High-Fat Diet-Fed Mice. This is a mouse study.

Clinical Study 7

Consumption of Pueraria flower extract reduces body mass index via a decrease in the visceral fat area in obese humans. This is a human study.

Clinical Study 8

Berberine protects against diet-induced obesity by regulating metabolic endotoxemia and gut hormone levels. This is a rat study.

Clinical Study 9

Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Mouse and human study.

Clinical Study 10

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease. This is a mouse study.

Clinical Study 11

Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice. This is a mouse study.

Clinical Study 12

Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. This is a rat study.

Clinical Study 13

Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. This is a study of skin cells.

Clinical Study 14

The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue. This is a rat study.

What Do All These Clinical Studies Mean?

Reviewing the available evidence for Exipure tells us:

• None of the cited research papers involved Exipure itself
• Those same studies reveal some of the ingredients in Exipure may promote a change of white fat into brown fat
• Most of the papers cited involve giving the ingredients to mice and rats

Does Exipure Not Work?

A lack of human evidence does not mean the supplement does not work. However, it would be nice if the company commissioned a study showing Exipure boosts brown fat production in people  – or better than that – a study showing Exipure helps people lose weight. If you are an Exipure customer, comment below and share your good or bad experiences to help others figure out if it really works.

Who Makes The Exipure Supplement Formula?

The company appears to simply be called “Exipure.” The company address is 1301 Ridgeview Dr, McHenry, IL 60050-7043. The owner of the company listed is Jack Barrett. The company website – ExiPure.com – was registered in June of 2021. The customer service phone number on file with the Better Business Bureau is 800-390-6035. The company phone number corresponds to ClickBank, an online retailer. This makes sense because Exipure is sold via the ClickBank online sales portal. They handle the sales. ClickBank is a respected online marketplace and a BBB-accredited business with an A+ rating that has been in service since 1998.

Exipure Real Customer Complaints

If you search the company website, you will see several positive testimonials from happy male and female customers. This is nice but like any popular supplement, you are bound to see both positive and negative customer reviews if you search long enough. No product can satisfy everybody. One possible factor that may play a role in some of the negative Exipure reviews is that ingredients in counterfeit Exipure may not contain the same ingredients.

Are fake Exipure supplements a real thing? Some online commentators have mentioned their supplements contained ketogenic ingredients, which would include exogenous ketone components such as beta-hydroxybutyrate (BHB) and medium-chain triglycerides (MCT oil). Neither of these ingredients is found in the official supplement that is being reviewed here.

Does Exipure Cause Ketosis?

To be clear, the Exipure formula reviewed here does not contain keto-friendly ingredients. If you look at the Official website for yourself, you will not see the words keto or ketogenic mentioned anywhere. The company does not claim that its supplement puts people into ketosis. That's not a bad thing because, despite the hype over keto supplements, their proof is pretty weak. To  learn more watch this video:

Do Keto Supplements Help With Safe Weight Loss?

Watch on my YouTube channel if you prefer.

Exipure Better Business Bureau Rating

When last checked, the Exipure company had an F rating with the Better Business Bureau. One factor that may play a role in the rating may be several unanswered customer complaints and disputes filed with the BBB. Addressing customer complaints may help improve companies' BBB ratings and give buyers more confidence in purchases. Complaints customers filed about the supplement include:

• not understanding the 180-day money-back guarantee refund policy
• difficulties obtaining Exipure refunds from the company

This appears to be a relatively new company. The BBB states the company started in January of 2021. When last checked, the company was not a BBB-accredited business. See the Better Business Bureau site for updates and more information.

Can You Trust Negative Exipure Customer Reviews?

Be careful with website reviews that are touted as being negative. This is true for many supplements too. Sometimes online articles calming to be “negative Exipure reviews” are not really negative but rather may be sponsored posts, written to get your attention and draw you away from real facts.  You can sometimes identify fake reviews by over-the-top titles, including words like shocking or exposed fraud, and even the word, legit. Words alone are no guarantee, so be on guard for reviews that contain sentences that make no sense or are outrageously grammatically incorrect and those that lead you to believe it's negative, yet only contain positive reviews.

TrustPilot Rating and Reviews

TrustPilot gives Exipure a 3 out of 5-star rating with 49% of people rating the supplement as “excellent” and 41% giving it a “poor” rating.  Reasons listed for complaining and rating it as poor include:

• the company not calming their TrustPilot profile
• the supplement not working
• the company not responding to people's complaints

The TrustPilot website states several fake Exipure reviews were posted to their website, which they removed.

Is Exipure on Amazon? Maybe Or Maybe Not…?

If you are looking to purchase this slimming supplement on Amazon or eBay you may see it listed. If you look closely, you will notice several companies offering this supplement. For example, you will see names like Vitalinia and S.O Labs. On eBay, other companies such as Organics Source, Max Bio, and NaturePure show up.

Is this a problem? As long as the ingredients in those bottles are the same no matter which company you get it from, then there are no issues.

Counterfeit Exipure Supplements?

How can you tell if the ingredients between companies are the same? You may have to play detective. Some customers on Amazon have stated versions they used are fake copycat supplements with ingredients that don't match the official formula, so double-check for yourself.

Whether what they are saying is legit or not is hard to say but if you're going to purchase Exipure from other websites, double-check the ingredients with those used by the main company. If companies do not display the Supplement Facts Label, then you need to reach out to them and request it. Here's where to find the official list of ingredients.

Exipure Refund and Money Back Guarantee Information

One area where Exipure exceeds expectations is in its return policy. Each bottle carries a 6-month money-back guarantee (180 days). So, you could test drive this brown fat-boosting supplement for several months and still get all your money back.

How To Return Exipure Instructions

You have 180 days to get a refund on Exipure. The 180 days start when you order the supplements. Not when the supplements arrive at your home.

To get a refund, follow these instructions:

Return ALL bottles that you received – even if they are empty. Return everything. Do NOT throw empty bottles in the trash.

Return the bottles to this address:

Exipure 1301 Ridgeview Dr. McHenry, IL 60050 (this is their fulfillment center)

Along with the bottles, also include:

• Your full name and address
• Your email address where the bottles were received and phone number
• Your ClickBank order ID, which is found on your receipt

When the company receives your returned items,  you can expect to receive the cost you paid credited back to you in 5-10 business days.

How To Contact Exipure Company If You Have Concerns or Questions

Their customer service can be reached by emailing the company at Contact@ExiPure.com. While the company does not list a customer service phone number, they do provide a phone number to Clickbank, which handles the sales. That number is 800-390-6035. If you reside outside the US, call 208-345-4245

What Does The FDA Say About Exipure?

Sometimes dietary supplement companies come under the scrutiny of the Food and Drug Administration (FDA). However, no  Exipure FDA warning letters or alerts were discovered. Likewise, no Federal Trade Commission (FTC) red flags were found either. These are good signs the company is adhering to US dietary supplement guidelines.

Exipure Negative Side Effects & Safty Instructions

There are no known negative adverse effects. To reduce any possible side effects you may have, here are some points of consideration. This list is not complete, so if you have any medical conditions, speak to your doctor and pharmacist for more specific instructions:

• Start with less for the first week. That way if you do experience adverse effects, taking less can help minimize them.
• Consult your doctor/pharmacist if you take blood thinner medications
• Stop taking at least two weeks before surgery due to possible anticoagulant effects
• Do not take if pregnant or breastfeeding. Holy basil and other Exipure ingredients may not be safe during pregnancy or nursing. Ask your doctor before taking this or any weight loss supplement.
• In animals, oleuropein appears to lower blood pressure
• Quercetin and holy basil may lower blood sugar levels if mixed with diabetes medications
• Holy basil may reduce thyroid hormone levels

Does Exipure Contain Sibutramine Or Other Hidden Ingredients?

Sibutramine was a prescription-only anti-obesity drug/appetite suppressant that is more commonly known as Meridia. While studies showed Meridia might help people lose 5% to 10% of body weight, it also raised blood pressure and heart rate, elevating the risk of heart attacks and strokes by about 10%. Other research suggests sibutramine may also cause cancer. In 2010 the FDA banned the use of sibutramine/ Meridia in the US. While the FDA has occasionally found sibutramine and other unapproved substances in some slimming supplements, there is no indication this prescription drug or others are found in Exipure. This is also a very good sign.

Exipure Pros & Cons

These are my opinions. Yours may be different.

Pros	Cons
Easy to order	No research on the supplement itself
180-day money-back guarantee	Some brands may contain different ingredients
Ingredients have research	Ingredients may come from other countries
Take only 1 capsule a day	Poor BBB rating
Non-GMO ingredients
3rd party tested for purity
Positive customer testimonials
One-time payment (no auto-shipments)
Manufactured in the USA

Is Exipure Worth It?

While several say Exipure is a legit weight loss supplement, it has not been clinically evaluated in humans to prove it increases brown fat production in humans or, more importantly, helps people lose significant amounts of body weight. To be fair, this is also true for other weight reduction dietary supplements too. I remain skeptical of the supplement's effectiveness. If you are intrigued by the positive testimonials and want to give it a try, the good news is Exipure's almost unmatched 180-day money-back guarantee if you feel you need a refund.

Here is the official website to learn more and get discounts