ProMind Complex is a memory supplement that is said to improve cognition by killing off bacteria that cause cavities and bad breath. Strange as it sounds, there's research linking bad oral hygiene to dementia, Alzheimer's, and early onset Alzheimers. That said, how good is Pro Mind Complex? Does it really work or is it just another internet scam? To help you figure out if it's legit, in this independent review, you'll discover the ingredients, research, who is Carl Henderson, pros, and cons, and how to get a refund if you need to.
What is ProMind Complex?
Pro-Mind Complex, is, as the name suggests, a memory improvement supplement. But, there's a twist. The makers of the supplement point to dental bacteria as the cause of memory problems like dementia and Alzheimer's disease. The bacteria (called Porphyromonas gingivalis) causes trouble when it travels from your mouth and gums up into your brain. Is this a hoax or are they on to something?
The bacteria produce a toxin called gingipains, which leads to memory impairment, serious memory loss, and Alzheimer's. They go on to say that if you use their simple breath test – smell your breath in the morning and have smelly breath – you have this bacteria and are at risk of having forgetfulness, memory impairment, and other age-related diseases in the future. Are they right? Is this for real?
Bacteria And Memory Loss
Research suggests dental bacteria may be linked to dementia. Researchers have found the gingipains toxin present in over 90% of people with Alzheimer's. When researchers infected brain cell stem cells with the dental bacteria Porphyromonas gingivalis (which makes gingipains), the toxin caused brain cells to die and reduced tau protein, which helps neurons stay healthy.
These bacteria also increase inflammation which is a risk factor for dementia and other diseases. This has led some researchers to call P. gingivalis a “strong risk factor” for Alzheimer's disease. It's not known if this is true for those who have occasional problems with remembering. Dental bacteria have also been found in artery-clogging plaque too, telling us they are linked to getting heart disease as well.
How Do You Take Pro Mind Complex?
Take 1 capsule per day. That's it. The company suggests taking ProMind right after breakfast or lunch. They say taking it this way will help you reap the benefits all day. Do not take ProMind on an empty stomach. Taking it on a full stomach will help you absorb the nutrients better. If you take it as directed a bottle will last you a month.
ProMind Complex Ingredients
The supplement facts label indicates 1 capsule has these ingredients and dosages
|Ingredient||Amount||Percent Daily Value|
|St. John's wort||250 mg||N/A|
|Bacopa monnieri||120 mg||N/A|
|N-Acetyl-L-Carnitine HCL||50 mg||N/A|
|Huperzine A||10 mcg||N/A|
N/A = no daily value established.
Other ingredients listed are gelatin, microcrystalline cellulose magnesium stearate, and silicon dioxide. These ingredients have no effect on how well the supplement works.
Is ProMind FDA Approved?
The FDA does not approve dietary supplements. What the FDA does do is regulate supplements. Regulation and approval are different. Generally, supplement companies do not need to seek permission or approval from the FDA before selling products to the public.
ProMind Complex Research
Does Pro Mind have any proof? Sort of yes and sort of no. While there appears to be no research on ProMind Complex itself, there is research on its ingredients. The idea behind the key ingredients is that they work better together than by themselves. This is sometimes called the entourage effect. While this appears to be real, there's no proof showing the combination of ingredients in ProMind has an entourage effect.
ProMind Complex Ingredients Research
St. John's Wort
St. John's wort has a long history of helping alleviate mild to moderate amounts of depression. But this is not why the company uses this herb. They use it to battle dementia and memory loss. Preliminary research suggests St. John's wort can improve memory in mice.The company says St. John's wort can ” scrape off the hardened plaque.” What's that about? Researchers have noted that in mice, St. John's wort reduces the accumulation of beta-amyloid protein, which forms the plaques found in people with Alzheimer's disease. Researchers have also reported the herb improves stress-related memory loss in rats.
Glutamine (L-glutamine) is an amino acid. It helps us make GABA, an important neurotransmitter. Humans make glutamine but sometimes they may need more. This is why it may be called a conditionally essential amino acid. Under some conditions, we may need more than we can make. Preliminary research suggests glutamine may aid learning and memory. When researchers inhibit the ability to make glutamine, memory declines. Some research suggests glutamine may protect the brain against Alzheimer's disease, although more research is needed.
Phosphatidylserine (PS) is a component of cell membranes and helps cells communicate with each other. The company says this ingredient “fires up brain cells.” In one investigation, PS was found to improve memory in people who likely had Alzheimer's disease. This study used 100 mg of PS taken 3 times a day (300 mg total). The Pro Mind Complex has 125 mg. In another study, 300 mg of PS was shown to improve memory and behavior when it was given to older people for 6 months. Other studies have also shown improvements in memory when given at a dosage of 300 mg a day for several months.
Bacopa is an herb and herbal supplement considered to have memory enhancement effects. The company says bacopa can “ward off anxiety and depression.” Substances called bacosides are thought to be at the heart of these benefits. Acetylcholine, a neurotransmitter, plays a role in memory. Research suggests bacopa can help keep acetylcholine normal by reducing it from being broken down. Some memory drugs and antidepressant drugs work this way too. Research also suggests bacopa may inhibit beta-amyloid protein which forms the plaques in the brains of those with Alzheimer's.
So does bacopa work? When given to middle-aged and older people, bacopa reduces forgetting new information. It helps people remember better. In other reports, bacopa was shown to improve memory and help people take less time when making decisions. Keep in mind several studies tend to use about 300 mg per day and last for 2-6 months. The Pro Mind Complex supplement has 120 mg.
Ginkgo biloba has long been associated with helping memory. The Pro Mind Complex says ginkgo will bulletproof both brain and gums against bacteria. Does it? When researchers in China gave ginkgo to people with severe gum disease, it significantly reduced periodontal microbes after just 1 week.
Reputation notwithstanding, if it works, it's unknown how well it works. In a review of several previous studies, ginkgo worked better at improving memory although the effects were not significantly different than a placebo. However, in another review ginkgo was shown to slow the decline in memory and cognition in older adults after 5 to 6 months of use. This review involved a specific extract of ginkgo biloba called EGb761. It is not known if ProMind Complex contains the EGb761 ginkgo extract.
In another review, researchers noted ginkgo was effective when used at dosages above 200 mg. However, in one interesting study ginkgo did not reduce the chances of getting dementia or Alzheimer's disease when it was given to people for up to 6 years. The dosage used was 240 mg per day.
This is another name for acetyl-l-carnitine, a substance humans make from the amino acids, methionine, and lysine. It can also be obtained from meats and dairy foods. In the body, L carnitine acts like a taxicab, transporting fats to the mitochondria where they are burned for energy.
Research shows that L-carnitine can increase nerve growth factors, raises acetylcholine levels, reduce inflammation, and has antioxidant effects. When given to old rats acetyl L carnitine improved brain function. Some studies have demonstrated L carnitines can slow the progression of Alzheimer's. Whlie more research is needed, studies may use 1-3 grams per day in research.
Vinpocetine is synthesized from the periwinkle plant and has been used in other countries to help memory problems. But does it work? The ProMind Complex company says vinpocetine repairs “wounded brain cells” and “opens up your brain's blood vessels, pumping your head full of oxygen and sparking nerve cells back to life.” Research shows vinpocetine increases blood flow to the brain so that appears to confirm some of what the company says.
Vinpocetine has also been shown to improve memory after 2 days in healthy people at a dosage of 40 mg, three times a day. Researchers in Nigeria reported vinpocetine improved memory in people with dementia and epilepsy although they also said the effects were minimal. In some countries, this vinpocetine may be sold by prescription under the name Cavinton.
Huperzine is a substance derived from the Chinese club moss (Huperzia serrata). The ProMind Complex company says that “Huperzine provides an antibacterial action on the surface of your brain.” Does it really do this? Researchers have isolated compounds from a fungus that grows on H. Serrata which exhibited antibacterial activity against staphylococcus aureus, a bacteria found in the biofilm on teeth, that causes cavities.
In China huperzine is approved as a drug to treat Alzheimer's. When researchers in China gave 0.2 mg (200 mcg) of huperzine to people with Alzheimer's disease, they reported that 58% of the people showed improvement in symptoms in memory, remembering new information, and behavior. ProMind Complex has 10mg per pill.
Some research has also shown huperzine might improve memory in younger persons too. One way it's thought to work is by reducing the breakdown of acetylcholine in the brain. This keeps acetylcholine levels higher and may help memory.
How Long Until Results Are Seen?
The company says fairly soon although this will vary from person to person and the memory problems you may have. My advice is to remember improvements in health take time. No supplement works overnight. This is especially true for getting your memory back. The company suggests giving Pro Mind at least 60 days to allow the nutrients enough time to work their way through your system several times.
ProMind Complex Price
To order, here are the prices listed on the official website:
- 1 bottle: $69 (1 month supply)
- 3 bottles $177 (3 month supply)
- 6 bottles $294 (6 month supply)
Prices may be different when you see this so check the website for updates.
All orders made within the US come with free shipping. Here are shipping rates for other countries:
- US: Free shipping
- Canada: $15.95
- UK and Ireland: $15.95
- Australia $15.95
- New Zeland: $15.95
It does not appear the supplement ships to South Africa, UK, or Australia however it may when you see this, so check the company website. When you place your order you will receive an email that lets you track when your package will arrive. The email will arrive within 60 hours (2.5 days) or ordering. Orders placed within the US arrive within 5-7 days. Orders shipped to other countries may take 10-15 working days.
ProMind Complex comes with a 60-day money-back guarantee. The 2-month guarantee begins when the supplements are shipped. Not
when they arrive. Also remember, if it really works, two months may not be enough time. It will depend on the severity of memory problems you are having. The company suggests giving it at least 2 months to work.
How To Get A Refund
If you are not happy, return the bottles to this address: 37 Inverness Drive East, Suite 100, Englewood, Colorado, 80112. You can even return bottles 59 days after your purchase. Remember to send back ALL of the bottles – both opened and unopened bottles.
You will get an email when they have received your returned bottles. If you have questions you can reach out to the company at contact AT promindcomplex.com.
Where Can You Buy ProMind?
You can purchase it from the official company website. Some websites such as Amazon may sell supplements that have the same name although they appear to be sold by different companies. Do they contain the same ingredients? Always ask to make sure.
Ask to see the supplement facts label. Without this information, it's difficult to know if their ingredients are the same as what is listed here. As such, it may be best to get it directly from the official company. ProMind is not sold locally at Walmart, CVS, Rite Aid, Kroger, Target, Vitamin Shoppe, or GNC although that may change in the future.
Customer Reviews & Complaints
If you're trying to find legitimate testimonials on how well it works, you may have difficulty. Not many negative complaints or consumer alerts could be located. The company website provides a testimonial of a man named “George H” a 79-year-old man in Miami Florida but nothing about him could be located. The Better Busines Bureau reports some complaints but one of the negative reviews appears unreasonable and outside the control of the company. Regardless, the company worked with the person to get a refund. Another person stated ProMind helped with brain fog. Another said it made him dizzy when he combined it with heart medications.
Who Makes ProMind Complex
The company is called The ProMind Complex, Inc. It appears to be a sole proprietorship that was started in 2020. The Offical website is ProMindComplex.com. While the company does not list a customer service phone number, the website has a contact page that you can reach out to with questions or to request refunds.
ProMind BBB Rating
The Better Business Bureau gives the company a B rating. Generally, that's not bad for a company of this age. While there are not many complaints what does exist shows the company responds to customer complaints and issues refunds when requested. Pro Mind Complex is sold by Clickbank, a trusted online retail website that has a BBB A+ rating that has been in business for over 20 years.
Who Is Carl Henderson?
Carl Henderson is the name you see on the supplement website. He's the man behind the Complex. He says he is a Ph.D. professor of psychology in Austin, Texas, and is said to be the person who perfected Pro Mind Complex. He's said to have come up with the formula after his wife accidentally left their grandchild in a hot car, only later to be diagnosed with Alzheimer's disease. He is a real person. He's in a Youtube video discussing the supplement. Not much could be found on him including no LinkedIn profile.
Dr. Jack Lane is said to be someone who helped Carl Henderson perfect the formula. If you are searching for who is Dr. Jack Lane is, you may have difficultly because while there are people with this name, that's not enough information to determine which Jack Lane Carl Henderson is referring to.
ProMind Complex Side Effects & Adverse Reactions
So is the complex safe? Some may say anyone can take the supplement this is not true. While no bad side effects are known from taking this supplement, there are some precautions. The company advises not to exceed the recommended dosage of 1 capsule per day. They also advise those with bleeding disorders or who are taking blood thinners and antidepressant medications such as MAO inhibitors to speak to their doctor first.
Some other things to consider include:
- Store in a cool, dry place. Don't use it if the safety seal is broken.
- Avoid if pregnant or breastfeeding
- St. John's wort may have many drug interactions. This even includes birth control pills. If you take any medications, ask your doctor first.
- Several ingredients may thin the blood. Stop taking the supplement at least 2 weeks before having surgery. This includes dental surgery.
- The supplement is not intended for those younger than 18
- If you have allergies, ProMind Complex is made in a facility that may also process milk, soy wheat eggs, peanuts, tree nuts, and shellfish.
ProMind Complex vs. Dentitox Pro
Dentitox Pro is a dental support product touted to improve your gums and teeth. Both supplements contain different ingredients but since ProMind Complex is said to help memory by eradicating cavity-causing microbes, could Dentitox Pro help it work better? As of now, maybe or maybe not. There is no proof either way. It would take clinical proof to know for sure and those have not been published yet. This is also true when comparing it to brain health supplements like Neuriva and Prevagen too.
Here is the Dentitox Pro official website to learn more about it.
ProMind Complex Pros & Cons
|Ingredients make sense||No research on supplement the itself|
|Ingredients have research||Some research is preliminary|
|Easy to purchase||Bold claims|
|60- day money-back guarantee||Kind of Pricey|
|Sold via A+ rated company|
Does ProMind Complex Really Work?
Until clinical studies are conducted, this question can't be answered. The real question is does ProMind clean the brain of the gingipains toxin found in the brains of so many Alzheimer's disease? While the ingredients make some sense, I think it's too soon to tell. If you try Pro Mind Complex, it probably won't work overnight. It will take a few months and that can vary from person to person and the kind of memory issues you are experiencing. I think bacopa and huperzine are key ingredients. While I remain skeptical, if it works, it may work best in people with mild memory issues who do not have severe dementia. On the plus side, if it's not right for you, you can get a refund if you desire.